There is no easy answer for this but here are some possible solutions

• Add Plutonium as an exception in your antivirus or uninstall it (do what is said for your antivirus in the documentation) https://plutonium.pw/docs/antivirus
• Repair your game: https://plutonium.pw/docs/repair/
• Update your GPU drivers
• Install DirectX (even if it's already installed): https://www.microsoft.com/en-us/download/details.aspx?id=35
• Download and run this script to install all the required redist: https://git.io/redists
• If you're running the game in a virtual machine don't, this doesn't work
• If you're using ReShade remove it. It's not supported on Plutonium and will make your game crash
• Close programs with overlays or disable their overlays (Steam, MSI Afterburner, Rivatuner etc.)
• Try to unplug devices connected to your PC (VR headset, other monitors, controllers etc.)
• If you use an Avermedia capture card uninstall its drivers
• Verify the integrity of your system files:
  Open the start menu and search for "cmd"
  Run cmd as admin
  Copy and paste (right click) each command below one by one in the cmd and press enter after each command
  Only put the next command when the one you ran is finished.

DISM /Online /Cleanup-Image /CheckHealth
DISM /Online /Cleanup-Image /ScanHealth
DISM /Online /Cleanup-Image /RestoreHealth
sfc /scannow

Once it's done restart your PC

As a last resort doing a clean install of Windows (factory reset) could solve the issue. Don't install your usual programs at first just install your GPU drivers, Direct X, your browser and Discord for example and test like that.