(This is based on pants guide)
If your game crashes with the error eventfd: Too many open files what fixed it for me was changing the start script a little bit:
#!/bin/bash
export WINEARCH=win64
export WINEPREFIX=~/.wine_plutonium
export WINEESYNC=1
wine plutonium.exe
change line 4, export WINEESYNC=1 to export WINEFSYNC=1
so your start script would look like this:
#!/bin/bash
export WINEARCH=win64
export WINEPREFIX=~/.wine_plutonium
export WINEFSYNC=1
wine plutonium.exe
and done! There shouldn't be any more crashes, I hope this helps someone.