Plutonium

You can create a GSC script to set this dvar automatically when the match starts.

Okay, so I installed Reshade and played BO2 Multiplayer for a while without any problem. HOWEVER, zombies actually crashes around 6 minutes into any match due to Reshade, with the "Oops! Plutonium T6 ran into a problem and must be closed." error message (which, if you look for it in the forums you can see that it is caused by using overlays or cheat engine). So there you go, Reshade is safe in mp, but not in Zombies. I hope this post has been helpful to the community. If there is a dev who is willing to give some more information on the topic, be welcome, but i think we have the answers to the question.

Did you try running it as admin? Also was there an plutonium.new.exe created as well in that folder? If yes, try running it as admin too.