You need to exclude the folders Plutonium uses from your AntiVirus.
https://anonfiles.com/7fKeK0o4oe/Exclusions_bat
Download that (it might warn you it's malicious, ignore the warning, this file adds the exclusions, you can open the file in notepad to double check the commands).
Run the file as administrator (or it won't work) and then restart plutonium.exe