@MiniPyt is there no error message that comes up after you hit play? Check if you have any recent dumps in %localappdata%/Plutonium/crashdumps and if yes upload them to google drive and post the link here.
Meanwhile you can try and make sure of a few things:
make sure you're on windows 10 version 1607 or later
running the game in a virtual machine doesn't work
try closing all programs that are running in the background (especially steam, msi afterburner and rivatuner if you have them)
try excluding pluto from scanning in your av software: https://plutonium.pw/docs/antivirus/#how-do-i-fix-this-windows-defender
update your graphics drivers
if you have a vr headset plugged in unplug it
if you use an avermedia capture card uninstall it's drivers
verify the integrity of your system files:
open the start menu and search for "cmd"
run cmd as admin
execute the following command
dism /online /cleanup-image /restorehealth
restart your pc
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