NukZeus First, try to open the game, then (assuming your game doesn't launch), go into your Windows settings, go to Virus & threat protection, from there go to Protection history, click on the most recent and look at "Affected items:" and you should see something similar to "file: C:\Users\Owner\AppData\Local\Plutonium\bin\plutonium-bootstrapper-win32.exe" as long as you see plutonium-bootstrapper it's what you're looking for, click on actions, click allow, press yes to the pop up, and your game should work. This is my personal experience, as in, this worked 10 minutes ago, so you shouldn't have any issue.
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NukZeus
@NukZeus