Donald Right click pluto, run as administrator. If that doesn't do it, add Pluto as well as %localappdata%/Plutonium to your AV's exclusions https://cdn.discordapp.com/attachments/762715587209068544/765331736917311538/Plutonium_Exclusion_Guide_MemeV1.mp4
If that still doesn't fix it, you're probably using some trash AVs like McAfee, avast, avg, bitdefender, etc. Uninstall them if you have them.