@Roj4s here's a few things you can try:
repair your installation: https://plutonium.pw/docs/repair/
running the game in a virtual machine doesn't work
try closing all programs that are running in the background (especially steam, msi afterburner and rivatuner if you have them)
try excluding pluto from scanning in your av software: https://plutonium.pw/docs/antivirus/#how-do-i-fix-this-windows-defender
update your graphics drivers
if you have a vr headset plugged in unplug it
if you use an avermedia capture card uninstall it's drivers
verify the integrity of your system files:
open the start menu and search for "cmd"
run cmd as admin
execute the following command
dism /online /cleanup-image /restorehealth
restart your pc
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