NukZeus First, try to open the game, then (assuming your game doesn't launch), go into your Windows settings, go to Virus & threat protection, from there go to Protection history, click on the most recent and look at "Affected items:" and you should see something similar to "file: C:\Users\Owner\AppData\Local\Plutonium\bin\plutonium-bootstrapper-win32.exe" as long as you see plutonium-bootstrapper it's what you're looking for, click on actions, click allow, press yes to the pop up, and your game should work. This is my personal experience, as in, this worked 10 minutes ago, so you shouldn't have any issue.

I'm stupid, first, try to open the game, then (assuming your game doesn't launch), go into your Windows settings, go to Virus & threat protection, from there go to Protection history, click on the most recent and look at "Affected items:" and you should see something similar to "file: C:\Users\Owner\AppData\Local\Plutonium\bin\plutonium-bootstrapper-win32.exe" as long as you see plutonium-bootstrapper it's what you're looking for, click on actions, click allow, press yes to the pop up, and your game should work. Have fun!

Whenever I try to open the game, I open the Plutonium launcher, and choose either versions of BO2 and nothing happens, I've re-installed the game, and restarted my computer (twice). I've followed the instructions to a T, and even went over it again when I re-installed it. What could be the issue?

EDIT: Yes, I have checked the FAQs for my issue.